Kambo: Definition, Ingredients, Application, Side Effects, Cost

Kambo is a traditional Amazonian ritual involving the use of the secretion from the Phyllomedusa bicolor frog, known for its potent bioactive compounds. The secretion is applied to minor burns or punctures made on the skin, where it is absorbed into the bloodstream, triggering various intense physiological and emotional effects.

Kambo contains a range of peptides and alkaloids, such as diamorphine, adenoregulin, and phyllo caerulein, each contributing to the secretion’s powerful effects, according to Medsafe in “Kambo – Kambô – leave it with frogs.” These compounds interact with the body’s systems differently, ranging from detoxification and immune system stimulation to pain relief and emotional release. 

Kambo is primarily used for its detoxifying properties, immune system enhancement, and emotional or spiritual cleansing. It is believed to help cleanse the body of toxins, boost the immune system, reduce chronic pain, and aid in psychological healing. The ritual is performed under the supervision of a trained practitioner, who guides the individual through the process while ensuring safety and efficacy. 

The side effects of Kambo include nausea, vomiting, diarrhea, rapid heart rate, and temporary emotional distress as the body reacts to the secretion. Though these short-term reactions are intense, they should not be undervalued. For individuals with certain health conditions, such as cardiovascular issues or mental health disorders, Kambo is not safe and should be avoided.

According to HealthCentral, the cost of Kambo varies between $100 and $300 per session, depending on factors such as location, practitioner expertise, and the length of the session. This price includes the secretion application and the practitioner’s preparatory and aftercare services. Despite its relatively high cost, many individuals choose to undergo the ritual for its potential benefits, including detoxification, pain relief, and emotional healing.

What is Kambo?

Kambo is a traditional healing ritual that involves the application of the secretion from the Phyllomedusa bicolor frog, also known as the giant leaf frog, which is native to the Amazon rainforest. The secretion is rich in bioactive peptides and is applied to minor burns or punctures on the skin, allowing the substances to be absorbed into the bloodstream. This secretion contains compounds believed to have various physiological effects, such as stimulating the immune system and increasing energy levels, according to Better Health.

Kambo is primarily used by indigenous tribes in the Amazon region for its purported medicinal properties. It is sought after for detoxification, immune system enhancement, and the treatment of conditions like chronic pain, infections, and even emotional blockages. Some also use it as a form of spiritual cleansing, as it is thought to purge both the body and mind.

Some people report feeling revitalized after the ritual of using Kambo, while others experience severe side effects such as nausea, vomiting, extreme discomfort, and even fainting. There have been cases of fatalities, mainly when the ritual is performed outside of traditional contexts or without proper supervision. The risks associated with Kambo largely stem from the potency of the frog secretion and the variability in individual responses to it.

Historically, Kambo has been used for centuries by indigenous tribes in the Amazon basin, where it is referred to as the “frog medicine.” It was traditionally applied before hunting expeditions to enhance strength and endurance, and it was believed to offer protection from disease. The practice has become more widely known and used in the Western world in recent decades as part of the broader interest in indigenous healing practices and alternative medicine.

What are the Ingredients in Kambo?

The ingredients in Kambo are a complex mixture of bioactive peptides, alkaloids, and other compounds secreted by the Phyllomedusa bicolor frog. These substances have various physiological effects, contributing to the unique properties of Kambo. 

The ingredients in Kambo are as follows:

• Dermorphin: Dermorphin is a peptide with potent pain-relieving properties. It is chemically similar to morphine but much more substantial. Its analgesic effects are up to 40 times more powerful than those of morphine, but unlike opioids, it is not considered addictive. Dermorphin’s primary action is on opioid receptors in the body, providing intense pain relief.
• Phyllocaerulein: Phyllocaerulein is a peptide that acts on the nervous system, mainly stimulating the release of adrenaline, according to a study by Thompson C et al. 2022, titled “Review of the physiological effects of Phyllomedusa bicolor skin secretion peptides on humans receiving Kambô.” It is believed to contribute to the stimulating effects of Kambo, promoting heightened alertness, increased energy, and potentially enhanced physical endurance. It also affects the cardiovascular system, increasing heart rate and blood pressure.
• Tyramine: Tyramine is an organic compound that promotes the release of norepinephrine, a neurotransmitter in the body’s “fight or flight” response. This compound leads to increased energy, heightened awareness, and sometimes a sense of euphoria. Tyramine also influences blood pressure, explaining some of Kambo’s cardiovascular effects.
• Bufotenine: Bufotenine is a psychoactive compound closely related to serotonin, a neurotransmitter that regulates mood regulation, according to a study by McBride MC. et al. 2000 in “Bufotenine: toward an understanding of possible psychoactive mechanisms.” Though bufotenine is sometimes classified as a hallucinogen, its effects, when applied topically, are not fully understood. Its presence in Kambo is believed to contribute to the emotional and psychological impact of the ritual, possibly aiding in emotional release and cleansing.
• Adenoregulin: Adenoregulin is a peptide that regulates the immune system. It is thought to have anti-inflammatory properties and help stimulate the body’s defense mechanisms. Adenoregulin contributes to Kambo’s reputed detoxifying and healing effects by influencing immune cell activity.
• Monobutyrin: Monobutyrin is a compound that promotes digestive health by stimulating the secretion of digestive enzymes. This action supports the body’s natural detoxification processes, potentially aiding in gastrointestinal function and improving overall digestion during the Kambo experience.
• Indolealkylamines: Indolealkylamines are a group of compounds that share structural similarities with serotonin and potentially affect mood, perception, and cognition. Although their precise role in Kambo’s effects is not fully understood, these compounds are believed to contribute to the emotional and psychological responses experienced during the ritual.

How Does Kambo Work?

Kambo works by introducing the secretion from the Phyllomedusa bicolor frog into the body through minor burns or punctures made on the skin. These bioactive compounds are absorbed into the bloodstream, interacting with the body’s systems to produce various physiological and psychological effects. 

Kambo works in the following ways:

• Absorption of Bioactive Compounds: Once applied to the skin, the secretion’s peptides, alkaloids, and other compounds are absorbed into the bloodstream through the small openings created in the skin. This direct entry allows the compounds to bypass the digestive system and interact quickly with the body’s internal systems.
• Immune System Stimulation: Some peptides in Kambo, such as adenoregulin, stimulate the immune system, promoting the activity of white blood cells and enhancing the body’s ability to fight off infections. This is one of the reasons Kambo is thought to have detoxifying properties, as it aids in clearing toxins from the body.
• Energy and Alertness Boost: Peptides like phyllo caerulein and tyramine release adrenaline and norepinephrine, neurotransmitters in the body’s stress response. This leads to increased energy, heightened alertness, and a sense of physical vigor, described as a “revitalizing” effect.
• Pain Relief: Dermorphin, a potent painkiller, acts on opioid receptors in the brain and body, providing intense pain relief. This analgesic effect is much stronger than morphine but does not carry the same addictive properties, making it useful in traditional healing for conditions involving chronic pain or discomfort.
• Psychological and Emotional Effects: Compounds like bufotenine, related to serotonin, contribute to emotional and psychological effects. Users report intense emotional experiences, including purging or releasing deep-seated emotions. This psychological cleansing is considered one of the benefits of Kambo, as it is believed to aid in mental clarity and emotional well-being.
• Physical Purging and Detoxification: Many people undergo Kambo to purge toxins from their bodies, which is a common result of the ritual. The secretion’s effects on the digestive, nervous, and immune systems combine to cause intense nausea, vomiting, sweating, and even diarrhea, which are part of the body’s natural detoxification process.

How Long Does It Take Kambo to Show Effects?

It takes just a few minutes for Kambo to show effects after application. Once the secretion is applied to the small burns or punctures on the skin, the bioactive compounds are rapidly absorbed into the bloodstream. Within 5 to 10 minutes, most people begin to experience the effects, which include a rapid heart rate, flushing, nausea, and sweating, as mentioned by Schmidt, T.T., Reiche, S., Hage, C.L.C. et al. 2020, titled “Acute and subacute psychoactive effects of Kambô, the secretion of the Amazonian Giant Maki Frog (Phyllomedusa bicolor): retrospective reports.” The peak intensity of the experience occurs within 15 to 20 minutes, with the overall process lasting around 30 to 60 minutes. While the immediate effects subside relatively quickly, some people report feeling lingering benefits, such as increased energy or emotional clarity, in the hours or days following the ritual.

How is Kambo Performed?

The Kambo is performed by applying the secretion of the Phyllomedusa bicolor frog onto small burns or punctures made on the skin, allowing the bioactive compounds to enter the bloodstream and trigger a cleansing process. The ritual involves preparation, application, monitoring, and recovery, conducted under the guidance of an experienced practitioner.

The Kambo is performed in the following way:

• Preparation: The individual undergoing Kambo is advised to fast for several hours before the session. They are also instructed to drink large amounts of water or herbal teas just before the ritual, which helps facilitate the purging process.
• Skin Preparation: The practitioner makes small burns or punctures on the skin using a heated stick or vine. These openings, referred to as “gates,” are made on specific areas of the body, such as the upper arm, leg, or back, depending on the individual’s needs or the tradition being followed.
• Application of the Secretion: The secretion from the Phyllomedusa bicolor frog is prepared by scraping it from the frog and drying it. It is then rehydrated and shaped into small dots or pellets, which are applied directly to the burns. This allows the bioactive compounds in Kambo to enter the bloodstream.
• Onset of Effects: Within minutes, the person begins to feel the effects of Kambo. These include a rapid heartbeat, flushing, sweating, nausea, and vomiting. Some individuals also experience diarrhea or emotional release. These symptoms are considered part of the cleansing and detoxification process.
• Observation and Support: The practitioner closely monitors the individual throughout the ritual, providing guidance and support as needed. The intense effects usually last for 20 to 40 minutes.
• Recovery: After the effects subside, the individual rests and rehydrates. Although they sometimes feel fatigued initially, they report a sense of clarity, calmness, or increased energy in the hours or days following the ritual.

How Long It Takes to Perform Kambo?

It takes approximately 30 to 60 minutes to perform Kambo, depending on the individual and the practitioner’s approach. The process begins with preparation, where the practitioner creates small burns or punctures on the skin and applies the frog secretion. The immediate effects of Kambo, such as nausea, vomiting, sweating, or flushing, peak within 15 to 20 minutes and subside after 30 to 40 minutes. Once the intense phase is over, the individual is given time to rest and rehydrate, which extends the overall session time to about an hour. The entire ritual takes up to two hours, including preparation and recovery.

What are the Applications of Kambo?

The applications of Kambo include detoxification, immune system enhancement, pain management, and emotional or spiritual cleansing. Its use is rooted in traditional Amazonian practices and has gained attention in alternative medicine for its potential therapeutic benefits. 

The applications of Kambo are as follows:

Detoxification

Kambo is commonly used for its detoxifying effects. The secretion triggers an intense purging process through vomiting, sweating, and sometimes diarrhea. This is believed to help eliminate toxins from the body and reset the digestive system. Those who feel sluggish, have digestive issues, or are exposed to environmental toxins opt for Kambo as a detoxifying ritual to promote overall well-being.

Immune System Enhancement

The peptides in Kambo, such as adenoregulin, are thought to stimulate the immune system, increasing the production of white blood cells and enhancing the body’s ability to fight infections and inflammation. This application benefits individuals with chronic infections, autoimmune conditions, or weakened immunity looking for a natural method to boost their health.

Pain Management

Kambo contains dermorphin, a peptide with potent analgesic properties that help alleviate chronic pain conditions. It acts on opioid receptors, providing relief without the addictive risks of traditional painkillers. People suffering from conditions like migraines, arthritis, or fibromyalgia explore Kambo as an alternative or complementary approach to managing pain.

Emotional and Spiritual Cleansing

The ritual is used for emotional release and psychological clarity. Compounds like bufotenine, which interact with serotonin pathways, help individuals process deep-seated emotions, reduce stress, and improve mood. This application is particularly appealing to those dealing with emotional trauma or stresses or seeking a spiritual connection and mental clarity.

Pre-Hunting Energy Boost (Traditional Use)

In indigenous traditions, Kambo was applied to warriors before hunting to enhance stamina, focus, and physical strength. The secretion’s effects on adrenaline and energy levels made it an effective preparation for demanding physical activity. Modern applications of this benefit appeal to athletes or individuals preparing for intense physical challenges.

Is Kambo a Potential Toxic Agent?

Yes, Kambo is considered a potential toxic agent. The secretion contains a complex mixture of bioactive peptides that, while offering therapeutic effects, also cause intense physiological reactions such as nausea, vomiting, diarrhea, and cardiovascular changes. 

In some cases, excessive use or improper application leads to severe complications, including dehydration, organ damage, or even death. These risks arise from the potency of the compounds and the body’s strong response to them. As such, Kambo should only be used under the supervision of a trained practitioner to reduce the likelihood of adverse effects.

Is Kambo Illegal?

No, Kambo is not illegal in most countries. It is unregulated, meaning medical authorities do not explicitly prohibit or approve its use in many regions. This lack of regulation means that Kambo practitioners operate in a legal gray area, and the safety and ethical standards of ceremonies vary widely. 

In some countries, such as Brazil, Kambo is recognized as part of traditional Amazonian medicine, while in others, its legal status depends on how it is marketed or administered. Always research local laws and ensure the practitioner follows safe and ethical practices before considering Kambo.

What are the Biological Effects of Kambo?

The biological effects of Kambo include detoxification, immune system stimulation, pain relief, cardiovascular changes, and emotional release. These effects occur due to the bioactive peptides and compounds in the secretion, which interact with various systems in the body. 

The biological effects of Kambo are as follows:

• Detoxification: Kambo induces a strong purging response through vomiting, sweating, and sometimes diarrhea. This occurs due to the secretion’s peptides, which trigger physiological processes that flush toxins and waste from the body, as studied by Keppel H et al. 2018 in “Kambo and its Multitude of Biological Effects.” The detoxification effect is intense and lasts about 20 to 40 minutes. It is beneficial for resetting the digestive system, enhancing metabolic processes, and promoting overall well-being.
• Anti-Inflammatory Effects: Some peptides in Kambo possess anti-inflammatory properties, reducing swelling and pain caused by inflammation. This effect benefits chronic inflammation conditions, such as arthritis or autoimmune disorders. The anti-inflammatory benefits last for hours to days, depending on the individual’s health and the severity of their condition.
• Immune System Stimulation: The peptides in Kambo, such as adenoregulin, activate immune cells and enhance the body’s defense mechanisms. This effect boosts white blood cell activity, making the body more resilient to infections and inflammation. The immune response lasts hours to days and is particularly beneficial for individuals with compromised immunity or chronic inflammatory conditions.
• Cardiovascular Changes: Peptides like phyllo caerulein and tyramine, which stimulate the release of adrenaline, temporarily cause the secretion to increase heart rate and blood pressure. This short-lived cardiovascular effect lasts 15 to 30 minutes and is part of the body’s heightened response to the compounds. While the effect is intense, it does not harm healthy individuals and temporarily improves circulation.
• Emotional and Psychological Effects: Compounds like bufotenine and other serotonin-related substances in Kambo influence mood and emotional processing. This leads to feelings of clarity, emotional release, or relief from stress. These effects last several hours to days, providing benefits for individuals seeking mental clarity or healing from emotional trauma.
• Pain Relief Effect: Kambo is a powerful analgesic that interacts with opioid receptors to alleviate pain, according to a study by Hesselink J.M.K., Schatman M.E. et al. 2018, titled “Rediscovery of old drugs: The forgotten case of dermorphin for postoperative pain and palliation.” This effect provides relief from chronic pain conditions such as arthritis, migraines, or fibromyalgia. The pain-relieving effects are immediate and last several hours a day. They contribute to longer-term improvement when used as part of a holistic approach.

What are the Side Effects of Kambo?

The side effects of Kambo include nausea, vomiting, diarrhea, sweating, rapid heart rate, dizziness, swelling, and fatigue. These short-term effects are considered part of the purging and detoxification process during the ritual.

Nausea and vomiting occur as the body reacts to the bioactive compounds, aiding in releasing toxins. Diarrhea and sweating are also common, as they are part of the body’s natural detox response. 

Some individuals experience dizziness or a rapid heart rate due to the peptides temporarily stimulating the cardiovascular system. Swelling and redness around the application sites appear but usually subside within a few hours. Fatigue follows the session as the body recovers from the intense physical and emotional release.

While most side effects are temporary, it is important to undergo Kambo under the guidance of an experienced practitioner to minimize risks and manage reactions appropriately.

How Often You Can Undergo Kambo?

You can undergo Kambo approximately once every 1 to 2 weeks, depending on your health, goals, and the advice of a trained practitioner. This allows the body enough time to recover and process the effects of the session. While Kambo offers powerful detoxification, immune stimulation, and other benefits, frequent use leads to physical or emotional fatigue due to the intensity of the experience.

Frequent use overstimulates the body’s systems, such as the cardiovascular system or the immune response, potentially leading to imbalance or exhaustion. The emotional purging that occurs during Kambo becomes overwhelming if done too often. Consulting a trained practitioner helps determine the appropriate frequency based on individual health and goals.

Who Should Avoid Kambo?

Individuals should avoid Kambo if they suffer from heart conditions or high blood pressure, are pregnant or breastfeeding, or have mental health conditions. These conditions are exacerbated by the intense physiological and emotional effects of Kambo, which put additional strain on the cardiovascular system, trigger psychological distress, or pose potential risks to fetal or infant health.

The following individuals should avoid Kambo:

• Individuals with Heart Conditions, High Blood Pressure, or Cardiovascular Problems: Kambo temporarily increases heart rate and blood pressure, further straining the cardiovascular system. For individuals already dealing with heart conditions, this heightened response leads to serious complications, such as arrhythmias, heart attacks, or strokes.
• Pregnant or Breastfeeding Women: The effects of Kambo on fetal or infant health are not well studied, and potential risks are involved. As a result, pregnant or breastfeeding women should avoid the ritual to prevent any possible harm to the baby or the mother.
• Individuals with Severe Mental Health Conditions: People with conditions such as schizophrenia, bipolar disorder, or other severe mental health issues find the emotional and psychological effects of Kambo overwhelming. The intense emotional purging exacerbates symptoms, and it is advised to avoid Kambo unless it is done under strict medical supervision.
• Individuals with Compromised Immune Systems: Those with weakened immune systems, whether due to conditions like HIV/AIDS or immunosuppressive treatments, should consult their healthcare provider before undergoing Kambo. The immune-stimulating effects of Kambo are too intense or potentially harmful in these cases.
• Those Taking Medications That Affect the Immune System or Blood Pressure: If you take medications that influence your immune system or blood pressure, it is important to consult a healthcare provider before considering Kambo. The interaction between Kambo’s compounds and certain medications leads to adverse effects.

How Much Does Kambo Cost?

Kambo costs between $100 and $300 per session, depending on the practitioner, location, and the facilitator’s experience level, according to HealthCentral. The price includes the session where the frog secretion is applied and additional services such as pre-session consultation, aftercare, and support during the ritual. 

In some cases, the cost also covers the use of ceremonial space or the guidance of a trained shaman or facilitator. Prices vary widely based on geographical location, with higher fees found in regions where Kambo is more popular or areas offering more specialized or private sessions. 

How Does Kambo differ from Ayahuasca?

The difference between Kambo and Ayahuasca are both traditional Amazonian practices but serve distinct purposes and involve different substances. Kambo utilizes the secretion of the Phyllomedusa bicolor frog, applied through small burns on the skin, to induce physical detoxification and boost the immune system. In contrast, Ayahuasca is a psychoactive brew made from the Banisteriopsis caapi vine and Psychotria viridis leaves, known for its hallucinogenic effects and spiritual insights. While Kambo primarily focuses on cleansing the body and enhancing vitality, Ayahuasca facilitates profound emotional and spiritual exploration, often accompanied by vivid visions and introspection.